Hong Kong Baptist University (HKBU) scholars demonstrated the design and synthesis of a smart globular macromolecular machine vehicle for actively controlled cancer drug delivery that enhances the drug’s efficacy. This breakthrough gives insight to targeted therapy drugs such as Chlorambucil in the treatment of leukemia. The paper, titled “Higher-Generation Type III-B Rotaxane Dendrimers with Controlling Particle Size in Three-Dimensional Molecular Switching,” was published in Nature Communications.