Phospholipids are water insoluble “building blocks” that define the membrane barrier surrounding cells and provide the structural scaffold and environment where membrane proteins reside. During the 62nd Biophysical Society Annual Meeting, held Feb. 17-21, in San Francisco, California, William Dowhan from the University of Texas-Houston McGovern Medical School will present his group’s work exploring how the membrane protein phospholipid environment determines its structure and function.