University of Washington and Microsoft researchers revealed today that they have taken a significant step forward in their quest to develop a DNA-based storage system for digital data. In a paper published in Nature Biotechnology, the members of the Molecular Information Systems Laboratory (MISL) describe the science behind their world record-setting achievement of 200 megabytes stored in synthetic DNA. They also present their system for random access—that is, the selective retrieval of individual data files encoded in more than 13 million DNA oligonucleotides. While this is not the first time researchers have achieved random access in DNA, the UW and Microsoft team have produced the first demonstration of random access at such a large scale.