Nanomedicines need to be taken up by diseased cells in order to release their cargo. Cancer cells have altered membrane properties that hamper their ability to take up nanomedicines. A research team led by Prof. Dr. Prasad Shastri at the University of Freiburg has shown that the stiffness of the cancer cell plasma membrane affects how nanoparticles are internalized, and this process can be enhanced when the cell plasma membrane stiffness is increased. These findings are published in Small.