Severe traumatic injuries to the cranium have been challenging to heal due to the large missing bone volume. Typically, metal or plastic implants are used. But, these implants can take a long time to be customized for fit and often take a longer than desired time to support bone fixation. This can often lead to multiple revision surgeries if the defect is not properly healed. Moreover, the tissue that adjoins the implant can improperly heal. For the effective treatment of these defects and injuries, it is necessary to reduce the time and improve the accuracy of implantable bone scaffold substitutes. Further, the microarchitecture and materials chemistry of the scaffold must enhance tissue regeneration and growth to hasten the healing process.