The human piece of a malaria infection puzzle has been revealed for the first time, solving a long-standing mystery. A protein displayed on the surface of malaria parasites called “TRAP” is a high-priority vaccine target, but how it interacts with human host cells has remained a puzzle. Scientists from the Wellcome Sanger Institute have discovered a receptor protein on the surface of human cells that the TRAP protein interacts with as it navigates through the body.