The U.S. Environmental Protection Agency’s (EPA) Integrated Risk Information System (IRIS) program has made “substantial progress” in implementing recommendations outlined in past reports by the National Academies of Sciences, Engineering, and Medicine, improving the program’s overall scientific and technical performance, says a new Academies report. The program, which is used to assess the hazards posed by environmental contaminants, remains a work in progress and should continue to evolve as it adapts and applies new scientific practices and knowledge, the report says.