Silk-based devices with antisense-miRNA therapeutics may enhance bone regeneration

Researchers have incorporated therapeutic microRNAs (miRNAs) into bioresorbable, silk-based medical devices such as screws and plates to achieve local delivery of factors that can improve bone growth and mineralization at the site of bone repair. The study, which demonstrated the promise of silk-based orthopedic devices combined with bioactive miRNA-based therapeutics, is published in Tissue Engineering, Part A.