In a Nature Communications paper published this week, IMEC, the world-leading research and innovation hub in nano-electronics and digital technology, describes a new concept for direct identification of single DNA bases. The technique has the potential to detect, with an unprecedented spatial resolution and without any labeling, the genetic code, as well as epigenetic variations in DNA. The combination of nanopore fluidics and surface enhanced Raman spectroscopy makes it a unique concept and a very promising tool for evolutionary biologists and for research on disease development.