One of the largest growing demographics in the EU is individuals aged 65 and over, and two thirds of this group are in situation of multimorbidity, i.e., perons who suffer from two or more chronic diseases. The ineffective treatment of multimorbidity has been pointed out as an urgent problem to address by the Academy of Medical Sciences in a recently released report. As part of an EU H2020 funded project called ProACT, our team at IBM Research – Ireland is working with partners in academia and industry to find new ways to use IoT, AI and cloud technologies to advance self-management capabilities and home-based integrated care for Persons with Multimorbidity (PwM).