We continue to improve our ability to read, write, and edit DNA on larger and larger scales. GP-write wants to gather and coordinate the global enthusiasm around large-scale genome engineering to bring about some major advancements in several areas. Overall, they have the goal to reduce of cost of building and testing large genomes by over 1,000-fold within ten years. This major reduction in cost would require large improvements in methods and technology, but large-scale projects like the synthesis of a human genome may be what’s needed to push the field to that point.