New research led by Holger Heyn at the Centro Nacional de Análisis Genómico of the Centre for Genomic Regulation (CNAG-CRG), presents a sophisticated computational framework to analyze single-cell gene expression levels, scalable to process millions of individual cells. The work, published in the current issue of the scientific journal Genome Research, reports the first tool capable of analyzing such large single-cell RNA-seq dataset. This dramatically extends the limits of single-cell genome research.