Abstract: Since its first measurement 20 years ago by the Infrared Space Observatory (ISO), the water (H2O) mole fraction in Titan’s stratosphere remains uncertain due to large differences between the determinations from available measurements. More particularly, the recent measurements made from the Herschel observatory (PACS (Photodetector Array Camera and Spectrometer) and HIFI (Heterodyne Instrument for the Far Infrared)) estimated the H2O mole fraction to be 0.023 parts per billion at 12.1 milliba…