Changes to small RNA in sperm may help fertilization

Two papers by UMass Medical School Professor Oliver J. Rando, MD, Ph.D., shed new light on the processes of fertilization and epigenetic inheritance in mammals. Together, the research provides important insight into how epigenetics—the study of inheritable traits that are carried outside the genome—work from father to offspring. The studies appear in the journal Developmental Cell and provide new information about the epigenetic contribution of males to their offspring.