Any bleeding results in a decrease of the amount of circulating blood, and the disruption of the adequate supply of tissues with oxygen can lead to death. An important measure aimed at correcting the pathological effects of acute blood loss is to restore the globular volume of blood. However, transfusion with erythrocyte mass is not always effective, since after prolonged storage, it can cause additional sludging and thrombosis of the microcirculatory bed, and as a result, deterioration of the blood gas transport function.