Years after the end of the Human Genome Project (HGP), which mapped the human genetic blueprint, its contributions to science and scientific culture are still unfolding. Ioannis Pavlidis, Eckhard Pfeiffer Professor of Computational Physiology at the University of Houston, UH doctoral student Dinesh Majeti and Alexander Petersen, professor of management at the University of California Merced, report in Science Advances that HGP scientists not only laid the groundwork for scientific breakthroughs for decades to come, but—because they worked together—brought to the mainstream a collaboration model that changed science’s cultural norms.