Fisheries management has often been characterized by regulatory policies that result in panaceas—broad based policy solutions that are expected to address several problems, which result in unintended consequences. An international research team shows how one size fits all policies like individual transferable quotas may be doomed from the onset, as these policies perpetuate “the panacea mindset.” The team calls for a more customized policy approach in a new piece in the Proceedings of the National Academy of Sciences.