Since the 1970s, astronomers and physicists have been gathering evidence for the presence in the universe of dark matter: a mysterious substance that manifests itself through its gravitational pull. However, despite much effort, none of the new particles proposed to explain dark matter have been discovered. In a review that was published in Nature this week, physicists Gianfranco Bertone (UvA) and Tim Tait (UvA and UC Irvine) argue that the time has come to broaden and diversify the experimental effort, and to incorporate astronomical surveys and gravitational wave observations in the quest for the nature of dark matter.