Ten years of commercial airliner-based measurements uniquely revealed three-dimensional distribution of atmospheric CO2 and its seasonality over Asia Pacific. Asia has been only sparsely monitored for atmospheric CO2, despite the growing importance of the region in the global carbon cycle. The remarkable feature of CO2 over Asia is depleted CO2 concentrations confined in the Asian summer monsoon anticyclone at the cruising altitude (approximately 10 km) imprinted by strong CO2 uptake by vegetation in South Asia.