Abstract: Centennial Challenges: Cube Quest – Propulsion, communication around Moon and into deep space; 3D-Printed Habitat – Additive construction for in-space habitats using regolith and recyclables; Vascular Tissue – 3D-printed human organ tissue to advance medicine in space and on Earth; CO2 Conversion – Bio-manufacturing using carbon dioxide and in-situ resources on Mars; Space Robotics II – Autonomous robotic navigation and decision systems for ISRU tasks.