Abstract: As NASA missions reach deeper into space, a few crew members will need to do the work of 10s-100s of Ground Controllers, most significantly, in critical areas such as trouble-shooting anomalies that could result in loss of crew or loss of mission. Understanding what the risk is of these sorts of events based on the history of the International Space Station allows us to anticipate how critical this challenge will be for future crewed missions, and allowing us to define the research that must …