Abstract: The International Space Station (ISS) Payload Operations and Integration Center (POIC) at NASA’s Marshall Space Flight Center (MSFC) in Huntsville, Alabama, United States, has gone through an evolution from supporting exclusively government ISS users to providing 50% (or more) of their support to commercial users. At the same time, they have expanded ground and facility operations to support a United States Orbital Segment crew expansion from three to four astronauts allowing an additional of…