Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a mouse model of MS, a team has identified a major regulator of Th17 cell-associated pathogenic inflammatory processes. The protein, Satb1, enhances the expression of genes promoting inflammation and suppresses genes needed to prevent autoimmunity. By targeting this protein, novel therapies may be able to attenuate inflammatory autoimmune diseases.