Healing is a complex process in adult skin impairments, requiring collaborative biochemical processes for onsite repair. Diverse cell types (macrophages, leukocytes, mast cells) contribute to the associated phases of proliferation, migration, matrix synthesis and contraction, coupled with growth factors and matrix signals at the site of the wound. Understanding signal control and cellular activity at the site could help explain the process of adult skin repair beyond mere patching up and more as regeneration, to assess biomechanics and implement strategies for accelerated wound repair in regenerative medicine.