On early earth, a series of spontaneous events needed to happen in order for life as we know it to begin. One of those phenomena is the formation of compartments enclosed by lipid membranes. New research by Irep Gözen, Elif Koksal, and colleagues at the University of Oslo reveals, for the first time, how these vesicles can self-assemble on surfaces without external input. The team discovered the most straight-forward and plausible explanation so far with the simplest assumptions. They will present their research at the 63rd Biophysical Society Annual Meeting, to be held March 2—6, 2019 in Baltimore, Maryland.