Nanoparticles can be used as substrates for computation, with algorithmic and autonomous control of their unique properties. However, scalable architecture to form nanoparticle-based computing systems is lacking at present. In a recent study published in Science Advances, Jinyoung Seo and co-workers in the Department of Chemistry at Seoul National University in South Korea, reported on a nanoparticle platform built in with logic gates and circuits at the level of the single particle. They implemented the platform on a supporting lipid bilayer. Inspired by cellular membranes in biology that compartmentalize and control signaling networks, the scientists called the platform “lipid nanotablet” (LNT). To conduct nano-bio-computing, they used a lipid bilayer as a chemical circuit board and the nanoparticles as units of computation.