Adjusting the frequency and dosage of Parkinson’s patients’ medication is complex. In their ‘ON’ state they respond positively to medication and in their ‘OFF’ state symptoms return. Addressing these fluctuations requires a clinical exam, history-taking or a patient’s self-report, which are not always practical or reliable. A new technology that combines an algorithm with a senor-based system using wearable motion sensors, automatically, continuously and reliably detects a patient’s medication ON and OFF states without patient or physician engagement.