Proteins are the workhorses of the cell. Their activity is often controlled by adding or removing chemicals called phosphates, like switching an electrical current on or off. Measuring how many proteins are phosphorylated, or turned on, has been a roadblock for research. Because phosphorylated proteins are hard to get in large amounts, they can be difficult to analyze, even using advanced instruments such as a mass spectrometer.
Click here for original story, Technology reveals previously undetectable protein signaling activity in diabetes, cancer
Source: Phys.org