Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa University and others discovered that caspase-1 proteolytically activates Bid and initiates apoptosis in GSDMD-deficient cells. Furthermore, cortical neurons and mast cells, exhibiting little GSDMD expression, undergo apoptosis after appropriate stimulation in a caspase-1- and Bid-dependent manner. This study clarifies molecular mechanisms and biological roles of caspase-1-induced apoptosis in GSDMD-low/null cells.
Click here for original story, Programmed cell death: The roles of caspase-1 and gasdermin D in apoptosis and pyroptosis
Source: Phys.org