A research team led by scientists at the Whitehead Institute has described the structure of a key protein complex that helps activate mTORC1, a master growth regulator that enables cells to quickly respond to changing nutrient levels. This activating complex includes two proteins, folliculin (FLCN), which is disrupted in an inherited tumor syndrome, and FNIP2. As described in the November 5 issue of Cell, the team’s findings reveal how FLCN and FNIP2 interact with each other and with other key components of mTORC1 to regulate nutrient and growth signals. These insights will help guide future studies, including the discovery of drugs that interfere with mTORC1 signaling.
Click here for original story, Team solves structure of key mTORC1 activator
Source: Phys.org