The proteins that constitute the extracellular matrix surrounding a cell exist as fibers. How the spacing between these matrix protein fibers affect clustering of the cell surface receptors integrins and how this influences the formation of integrin-mediated cell-matrix adhesions and subsequent cell spreading was the focus of a recent study led by Dr. Rishita Changede, Senior Research Fellow at the Mechanobiology Institute, National University of Singapore. The study was published in Nature Materials.
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Source: Phys.org