Mechanism for how common gene therapy vectors enter cells

Researchers have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types — the most commonly used viral vectors for in vivo gene therapy. The researchers identified that GPR108, a G protein-coupled receptor, served as a molecular ‘lock’ to the cell. The discovery could one day enable scientists to better direct AAV gene transfers to specific tissues.


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Source: ScienceDaily