Scientists have designed and synthesized chains of molecules with a precise sequence and length to efficiently protect 3-D DNA nanostructures from structural degradation under a variety of biomedically relevant conditions. They demonstrated how these “peptoid-coated DNA origami” have the potential to be used for delivering anti-cancer drugs and proteins, imaging biological molecules, and targeting cell-surface receptors implicated in cancer. Their method for designing peptoids to stabilize DNA origami in physiological environments is described in a paper published in the Proceedings of the National Academy of Sciences the week of Mar. 9.
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Source: Phys.org