A group of scientists from CECAD has found a mechanism by which neurodevelopmental diseases concerning neurons can be explained. The loss of a certain enzyme, UBE2K, impedes the differentiation of stem cells by silencing the expression of genes important for neuronal differentiation and, therefore, the development and generation of neurons. More specifically, UBE2K regulates the levels and activation of histones, key proteins that pack and organize DNA, regulating the expression of genes. Being part of the epigenetic landscape of the cell, the changes made to the histones are reversible and could provide a chance for future treatments for neurodevelopmental diseases. The study is published in the current issue of Communications Biology.
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Source: Phys.org