Three teams working independently to test the possibility of using CRISPR–Cas9 gene editing to remove genetic defects in human embryos report finding unwanted changes in the genomes. The first team, working at the Francis Crick Institute, edited mutations that can have a major impact on fetal development. The second, working at Columbia University tried to use the gene editor to fix a mutation known to cause blindness. And the third was a team working at Oregon Health & Science University—they were attempting to fix a mutation known to cause a certain heart problem. All three groups have written papers describing their efforts and findings, and have posted them on the bioRxiv preprint server while they await peer-review.
Click here for original story, Three new studies show unwanted changes in human embryo genome after CRISPR-Cas9 editing
Source: Phys.org