With increasing age, and especially in neurodegenerative diseases such as Alzheimer’s, proteins tend to misfold and aggregate into harmful deposits both inside and outside cells. Secreted proteins play an important role in regulating body functions and fighting infections. Now a collaborative team at the University of Tübingen has discovered mechanisms to stop secreted proteins from forming deposits outside the cell. The team is headed by Della David, who researches aging, at the Interfaculty Institute of Biochemistry and at the German Center for Neurodegenerative Diseases (DZNE). The findings indicate that keeping proteins in shape in body fluids helps to combat both aging and infections. The study has been published in the latest edition of Nature.
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Source: Phys.org