Researchers of the University of Bayreuth and the Columbia University in New York reported groundbreaking findings on protein biosynthesis in bacteria in the journal iScience. The small protein NusG links the two large molecular machines that work together during gene expression, which is the production of bacterial proteins based on genetic information: RNA polymerase and the ribosome. The molecular bridge enables the bacterial cell to synchronize perfectly the successive stages of gene expression, i.e., transcription and translation. Thus, this connection could be an excellent target for future antibiotic drugs.
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Source: Phys.org