Both influenza virus M2, a proton-selective ion channel essential for efficient viral replication, and PB1-F2 protein, which localizes to the mitochondria and attenuates host antiviral immunity, are involved in the inflammatory response by stimulating NLRP3 inflammasome-dependent IL-1β secretion. However, the precise mechanisms by which these viral proteins activate the NLRP3 inflammasome remain unclear.
Click here for original story, Influenza virus-induced oxidized DNA activates inflammasomes
Source: Phys.org