In cells, there are proteins that do the work and proteins that regulate them. The latter inhibit or enhance activity, depending on the need. However, in many diseases—for example cancer—there is so much overactivity in the cell that the regulator proteins can no longer keep up with it. Researchers at Eindhoven University of Technology therefore developed a kind of molecular “glue” in 2019 that helps the regulator to inhibit faster. Now this technique has been further developed, and the researchers have found a completely unexpected way to look for new protein-gluing molecules. This offers prospects for the development of drugs for cancer, diabetes or cystic fibrosis, for example. They published their results last week in Nature Communications.
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Source: Phys.org