Glycans in the SARS-CoV-2 spike protein play active role in infection

As the COVID-19 pandemic rages on, researchers are working overtime to develop vaccines and therapies to thwart SARS-CoV-2, the virus responsible for the disease Many efforts focus on the coronavirus spike protein, which binds the angiotensin-converting enzyme 2 (ACE2) on human cells to allow viral entry. Now, researchers reporting in ACS Central Science have uncovered an active role for glycans—sugar molecules that can decorate proteins—in this process, suggesting targets for vaccines and therapies.


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Source: Phys.org