Chemotherapy is defined as the use of chemicals to reach and damage cancer cells. On its way toward the tumor, the drugs can affect healthy cells, as well. For example, cisplatin, a common drug used in clinical treatments, is not selective and causes unwanted secondary effects such as vomiting, fever and loss of sensitivity, among others. These effects often halt the treatment. It is of great importance to find new drugs that can be selectively activated in the tumor for more effective treatments. Understanding the interaction mechanism of new drug candidates within the cell nano-environment is the first step toward reaching the clinic.
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Source: Phys.org