Scientists at Tokyo Institute of Technology have deciphered how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. Using their method, they successfully generated reconstituted chromatin-bearing histone modifications in vitro. Their study published in Nucleic Acids Research provides an accurate quantitative approach for understanding how site-specific changes to histone proteins impact the accessibility of chromatin and gene expression levels.
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Source: Phys.org