Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA. This advance expands the scope and clinical applicability of nucleic-acid therapeutics across an ever-widening swathe of intractable diseases including neurological disorders.
Click here for original story, Making therapeutic sense of antisense oligonucleotides
Source: ScienceDaily