Considered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. New findings demonstrate a previously-unknown capability for polymerase theta (pol theta) – a key enzyme in this repair function—that shows promise as a new avenue for treatment development.
Click here for original story, Study identifies never-before-seen dual function in enzyme critical for cancer growth
Source: Phys.org