Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease. The app reveals potentially risky DNA alterations that could impede efforts to safely use CRISPR to correct mutations in conditions like sickle cell disease and cystic fibrosis. The development of the new tool, called DECODR (which stands for Deconvolution of Complex DNA Repair), was reported today in The CRISPR Journal by researchers from ChristianaCare’s Gene Editing Institute.
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Source: Phys.org