Atropisomers are a class of stereoisomers (chemical compounds that differ in spatial arrangement of atoms) arising from restricted rotation around a single bond and have various applications in chemistry. To date, most research on atropisomers has focused on “biaryl atropisomers” (due to the rotational restriction around a carbon-carbon bond), but it is also possible for atropisomers to arise from rotational restrictions around a nitrogen-carbon (N-C) bond. These N-C axially chiral compounds are found in various natural products and bioactive compounds and thus have promising applications in medicine and agriculture. Furthermore, these are known to be useful as chiral building blocks and chiral ligands.
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Source: Phys.org