Researchers from the group of Hans Clevers identified and characterized rare cell types in the upper gastrointestinal tract. Using single cell RNA sequencing, they studied the cellular composition of the esophagus, stomach and upper part of the small intestine. They provide detailed gene expression analyses for all epithelial cells in these organs. Furthermore, they identified a rare cell type that is most likely responsible for the secretion of high volumes of water in humans. This cell type provides a link to gastrointestinal defects in patients with cystic fibrosis. The paper was published in Cell Reports on the 9th of March and serves as a resource for other scientists in the field.
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Source: Phys.org