Prime editing (PE), a ‘search-and-replace’ CRISPR-based genome editing technique, has great potential for gene therapy and agriculture. It can introduce desired base conversions, deletions, insertions, and combination edits into target genomic sites. Prime editors have been successfully applied in animals and plants, but their off-target effects, which can be a major hindrance to real-life application, have not been thoroughly evaluated until now.
Click here for original story, Researchers demonstrate very high specificity of prime editors in plants
Source: Phys.org