Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals, and in industry, like in the method for identifying COVID-19. Phosphoramidites are necessary building blocks in the production of DNA sequences, but they are unstable, and break quickly. Ph.D. Alexander Sandahl (Professor Kurt Gothelf’s group, Aarhus University) has, in collaboration with a researcher in Professor Troels Skrydstrup’s group, developed a new patented way to quickly and efficiently manufacture the unstable building blocks immediately before they are to be used, and thus streamline DNA production.
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Source: Phys.org