Biomimetic catalysis is an emerging concept that emulates key features of enzymatic process. Prenylation is a ubiquitous process found in almost all living organisms. Inspired by the enzymatic mechanism, researchers developed a selective C2 prenylation of indoles via chemical catalysis, which can be applied to late-stage diversification of tryptophan-based peptides and concise synthesis of tryprostatin B.
Click here for original story, Bioinspired acid-catalyzed C2 prenylation of indole derivatives
Source: Phys.org